Article
A multicentre randomised trial to compare the efficacy of omeprazole versus rabeprazole in early symptom relief in patients with reflux esophagitis.
Journal of gastroenterology - 1 Dec 2014
Nagahara Akihito, Suzuki Tsuyoshi, Nagata Naoyoshi, Sugai Nozomu, Takeuchi Yoshiaki, Sakurai Kouichi, Miyamoto Masaki, Inoue Kazuhiko, Akiyama Junichi, Mabe Katsuhiro, Konuma Ichiro, Kamada Tomoari, Haruma Ken
Abstract excerpt
BACKGROUND: Proton pump inhibitors (PPIs) are affected by cytochrome P450 2C19 (CYP2C19) polymorphisms. This study compared the effect of two PPIs on early symptom relief in Japanese patients with reflux esophagitis, classified by the CYP2C19 phenotype. METHODS: Patients with reflux esophagitis were randomised to treatment with omeprazole 20 mg or rabeprazole 10 mg once daily. The CYP2C19 phenotype [homozygous...
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