Article
Neonatal and adult microglia cross-present exogenous antigens.
Glia - 1 Jan 2008
Beauvillain Celine, Donnou Sabrina, Jarry Ulrich, Scotet Mari, Gascan Hugues, Delneste Yves, Guermonprez Pierre, Jeannin Pascale, Couez Dominique
Abstract excerpt
Some observations have suggested that cells from the central nervous system (CNS) could present exogenous antigens on major histocompatibility complex (MHC) class I molecules to CD8(+) T cells (a process called cross-presentation). Microglia are the major myeloid immunocompetent cells of the CNS. When activated, following the injury of the nervous parenchyma, they become fully competent antigen-presenting cells...
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