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Article

Proteomics of transformed lymphocytes from a family with familial pulmonary arterial hypertension.

American journal of respiratory and critical care medicine - 1 Jan 2008

Meyrick Barbara O, Friedman David B, Billheimer D Dean, Cogan Joy D, Prince Melissa A, Phillips John A, Loyd James E

Abstract excerpt

RATIONALE: Not all family members with BMPR2 mutations develop pulmonary arterial hypertension (PAH), implying that additional modifier genes or proteins are necessary for full expression of the disease. OBJECTIVES: To determine whether protein expression is altered in patients with familial PAH (FPAH) compared with obligate carriers and nondiseased control subjects. METHODS: Protein extracts from transformed...

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Topics

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Share to Bone Morphogenetic Protein Receptors, Type II
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Carrier Screening

Share to Hypertension, Pulmonary

Share to Lymphocyte Activation

Share to Proteomics

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 17932379
DOI: 10.1164/rccm.200703-499OC
PMCID: PMC2176118

Genes

BMPR2
PAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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