Article
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population.
Journal of human genetics - 1 Jan 2007
Jacq Laurent, Teixeira Vitor Hugo, Garnier Sophie, Michou Laëtitia, Dieudé Philippe, Rocha Dominique, Pierlot Céline, Lemaire Isabelle, Quillet Patrick, Hilliquin Pascal, Mbarek Hamdi, Petit-Teixeira Elisabeth, Cornélis François
Abstract excerpt
The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single...
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