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Article

Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes.

American journal of physiology. Endocrinology and metabolism - 1 Dec 2007

Marini Juan C, Erez Ayelet, Castillo Leticia, Lee Brendan

Abstract excerpt

The spf-ash mutation in mice results in reduced hepatic and intestinal ornithine transcarbamylase. However, a reduction in enzyme activity only translates in reduced ureagenesis and hyperammonemia when an unbalanced nitrogen load is imposed. Six-week-old wild-type control and spf-ash mutant male mice from different genetic backgrounds (B6 and ICR) were infused intravenously with [(13)C(18)O]urea,...

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Identifiers

PMID: 17925451
DOI: 10.1152/ajpendo.00525.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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