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Article

Ex Vivo Enteroids Recapitulate In Vivo Citrulline Production in Mice.

The Journal of nutrition - 1 Sept 2018

Wang Xiaoying, Yuan Yang, Didelija Inka C, Mohammad Mahmoud A, Marini Juan C

Abstract excerpt

Background: The endogenous production of arginine relies on the synthesis of citrulline by enteral ornithine transcarbamylase (OTC). Mutations in the gene coding for this enzyme are the most frequent cause of urea cycle disorders. There is a lack of correlation between in vivo metabolic function and DNA sequence, transcript abundance, or in vitro enzyme activity. Objective: The goal of the present work was to...

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Source

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Identifiers

PMID: 30184221
DOI: 10.1093/jn/nxy126
PMCID: PMC6669957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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