Article
Effect of mutations in the beta5-beta7 loop on the structure and properties of human small heat shock protein HSP22 (HspB8, H11).
The FEBS journal - 1 Nov 2007
Kasakov Alexei S, Bukach Olesya V, Seit-Nebi Alim S, Marston Steven B, Gusev Nikolai B
Abstract excerpt
The human genome encodes ten different small heat shock proteins, each of which contains the so-called alpha-crystallin domain consisting of 80-100 residues and located in the C-terminal part of the molecule. The alpha-crystallin domain consists of six or seven beta-strands connected by different size loops and combined in two beta-sheets. Mutations in the loop connecting the beta5 and beta7 strands and...
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