Article
Recipient cytotoxic T lymphocyte antigen-4 +49 G/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients.
Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2007
Jiang Zhijun, Feng Xiaoning, Zhang Wu, Gao Feng, Ling Qi, Zhou Lin, Xie Haiyang, Chen Qixing, Zheng Shusen
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNP) of two-gene locus cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 and CD86 +1057 were previously reported to influence the outcome of liver transplantation (LT) with respect to allograft acceptance. SNP at CTLA-4 +49 was also suggested to be associated with the individual difference in the clearance of hepatitis B virus (HBV). However, their influence on the...
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