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Article

Survivin repression by p53, Rb and E2F2 in normal human melanocytes

4 Oct 2007

Abstract excerpt

The inhibitor of apoptosis protein survivin is a dual mediator of apoptosis resistance and cell cycle progression and is highly expressed in cancer. We have shown previously that survivin is up-regulated in melanoma compared with normal melanocytes, is required for melanoma cell viability, and that melanocyte expression of survivin predisposes mice to ultraviolet-induced melanoma and metastasis. The mechanism of...

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Identifiers

PMID: 17916908
DOI: 10.1093/carcin/bgm219

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Related research

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Survivin repression by p53, Rb and E2F2 in normal human melanocytesPMID 17916908Read ↗

Aberrant regulation of survivin by the RB/E2F family of proteins.Semantic proximity Read ↗

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P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferationSemantic proximity Read ↗

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.Semantic proximity Read ↗

Skp2 regulates G2/M progression in a p53-dependent manner.Semantic proximity Read ↗

alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.Semantic proximity Read ↗

Survivin splice variants are not essential for mitotic progression or inhibition of apoptosis induced by doxorubicin and radiationSemantic proximity Read ↗

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosisSemantic proximity Read ↗

Survivin splice variants regulate the balance between proliferation and cell death.Semantic proximity Read ↗

Survivin protein in UVB induced apoptosis of melanoma cells and in melanoma progression.Semantic proximity Read ↗

p21/CDKN1A mediates negative regulation of transcription by p53.Semantic proximity Read ↗

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