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Article

Aberrant regulation of survivin by the RB/E2F family of proteins.

The Journal of biological chemistry - 24 Sept 2004

Jiang Yuying, Saavedra Harold I, Holloway Michael P, Leone Gustavo, Altura Rachel A

Abstract excerpt

Survivin is a putative oncogene that is aberrantly expressed in cancer cells. It has been hypothesized to play a central role in cancer progression and resistance to therapy in diverse tumor types. Although some of the transcriptional processes regulating its expression have been established, the diversity of genes that may be controlling the levels of its expression in both normal cells as well as in cancer...

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PMID: 15271987
DOI: 10.1074/jbc.M404496200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Aberrant regulation of survivin by the RB/E2F family of proteins.PMID 15271987Read ↗

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Epigenetic mechanism of survivin dysregulation in human cancerSemantic proximity Read ↗

Overexpression of survivin initiates hematologic malignancies in vivo.Semantic proximity Read ↗

Role of E2F in cell cycle control and cancerSemantic proximity Read ↗

E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression.Semantic proximity Read ↗

Survivin splice variants are not essential for mitotic progression or inhibition of apoptosis induced by doxorubicin and radiationSemantic proximity Read ↗

Survivin: Role in Normal Cells and in Pathological ConditionsSemantic proximity Read ↗

Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic StrategiesSemantic proximity Read ↗

Survivin study: an update of "what is the next wave"?Semantic proximity Read ↗

Gene expression changes in response to E2F1 activationSemantic proximity Read ↗

A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells.Semantic proximity Read ↗

A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells.Semantic proximity Read ↗

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