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Article

Mutational spectrum of dihydropyrimidine dehydrogenase gene (DPYD) in the Tunisian population.

Comptes rendus biologies - 1 Oct 2007

Ben Fredj Radhia, Gross Eva, Chouchen Lotfi, B'Chir Fatma, Ben Ahmed Slim, Neubauer Steffi, Kiechle Marion, Saguem Saâd

Abstract excerpt

Dihydropyrimidine dehydrogenase enzyme (DPD) deficiency is a pharmacogenetic syndrome leading to severe side-effects in patients receiving therapies containing the anticancer drug 5-fluorouracil (5-FU). The aim of this population study is to evaluate gene variations in the coding region of the dihydropyrimidine dehydrogenase gene (DPYD) in the Tunisian population. One hundred and six unrelated healthy Tunisian...

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Source

Identifiers

PMID: 17905396
DOI: 10.1016/j.crvi.2007.08.003

Genes

DPYD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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