Lack of association between HLA-DR antigens and sleep-onset REM periods in major depression.

doi:10.1016/0006-3223(91)90156-g

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Lack of association between HLA-DR antigens and sleep-onset REM periods in major depression.

Biological psychiatry - 15 Dec 1991

Staner L, Bouillon E, Andrien M, Dupont E, Mendlewicz J

Abstract excerpt

Narcolepsy is the disease disclosing the strongest association with the HLA system. Almost 100% of cases are associated with HLA-DR2 antigen. Moreover, narcolepsy is often characterized by the occurrence of sleep-onset REM (SOREM) periods. SOREM has also been demonstrated in major depression. To further investigate the relationship between SOREM and HLA-DR2, HLA-DR and HLA-DQ antigens were assessed in 50 research...

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Lack of association between HLA-DR antigens and sleep-onset REM periods in major depression.

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