Article
Increase in Fru-2,6-P(2) levels results in altered cell division in Schizosaccharomyces pombe.
Biochimica et biophysica acta - 1 Jan 2008
Fernández de Mattos Silvia, Alemany Vicenç, Aligué Rosa, Tauler Albert
Abstract excerpt
Mitogenic response to growth factors is concomitant with the modulation they exert on the levels of Fructose 2,6-bisphosphate (Fru-2,6-P2), an essential activator of the glycolytic flux. In mammalian cells, decreased Fru-2,6-P2 concentration causes cell cycle delay, whereas high levels of Fru-2,6-P2 sensitize cells to apoptosis. In order to analyze the cell cycle consequences due to changes in Fru-2,6-P2 levels,...
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