Article
Analysis of sequence variations in 59 microRNAs in hepatocellular carcinomas.
Mutation research - 1 Feb 2008
Yang Jine, Zhou Fan, Xu Teng, Deng Hua, Ge Yi-Yuan, Zhang Changqing, Li Jinqing, Zhuang Shi-Mei
Abstract excerpt
It is well demonstrated that mutations in protein-coding genes play a key role during carcinogenesis. Whether sequence variations in microRNA genes are also associated with tumorigenesis is still unknown and thus require extensive investigations. In the present study, genomic sequences coding for the precursors of 59 microRNA genes were analyzed in both hepatocellular carcinoma (HCC) tissues and liver cancer...
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