Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development.

Journal of virology - 1 Dec 2007

Shiboleth Yoel Moshe, Haronsky Elina, Leibman Diana, Arazi Tzahi, Wassenegger Michael, Whitham Steven A, Gaba Victor, Gal-On Amit

Abstract excerpt

The helper component-proteinase (HC-Pro) protein of potyviruses is a suppressor of gene silencing and has been shown to elicit plant developmental-defect-like symptoms. In Zucchini yellow mosaic virus (ZYMV), a mutation in the highly conserved FR180NK box of HC-Pro to FI180NK causes attenuation of these symptoms. At 5 days postinoculation and before symptoms appear, virus accumulation, HC-Pro protein levels, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Cucurbita

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine Endopeptidases

Share to MicroRNAs

Share to Plant Diseases

Share to Potyvirus

Share to RNA, Small Interfering

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17898058
DOI: 10.1128/JVI.01031-07
PMCID: PMC2169133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development.PMID 17898058Read ↗

Discriminating mutations of HC-Pro of zucchini yellow mosaic virus with differential effects on small RNA pathways involved in viral pathogenicity and symptom development.Semantic proximity Read ↗

The potyviral silencing suppressor HCPro recruits and employs host ARGONAUTE1 in pro-viral functions.Semantic proximity Read ↗

Structural characterization of HC-Pro, a plant virus multifunctional protein.Semantic proximity Read ↗

A Newly Identified Virus in the Family Potyviridae Encodes Two Leader Cysteine Proteases in Tandem That Evolved Contrasting RNA Silencing Suppression Functions.Semantic proximity Read ↗

Mutations in the HC-Pro gene of zucchini yellow mosaic potyvirus: effects on aphid transmission and binding to purified virions.Semantic proximity Read ↗

Sequence variability in the HC-Pro coding regions of Korean soybean mosaic virus isolates is associated with differences in RNA silencing suppression.Semantic proximity Read ↗

HC-Pro silencing suppressor significantly alters the gene expression profile in tobacco leaves and flowers.Semantic proximity Read ↗

RNA Silencing Suppression by a Second Copy of the P1 Serine Protease of<i>Cucumber Vein Yellowing Ipomovirus</i>, a Member of the Family<i>Potyviridae</i>That Lacks the Cysteine Protease HCProSemantic proximity Read ↗

A high level of transgenic viral small RNA is associated with broad potyvirus resistance in cucurbits.Semantic proximity Read ↗

Tomato Spotted Wilt Virus NSs Protein Supports Infection and Systemic Movement of a Potyvirus and Is a Symptom Determinant.Semantic proximity Read ↗

Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro.Semantic proximity Read ↗

Viral Protein Inhibits RISC Activity by Argonaute Binding through Conserved WG/GW MotifsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.