Article
Suppression of nuclear Wnt signaling leads to stabilization of Rac1 isoforms.
FEBS letters - 16 Oct 2007
Esufali Susmita, Charames George S, Bapat Bharati
Abstract excerpt
The Rac1 GTPase contains a functional nuclear localization signal (NLS) and destruction box sequence in the C-terminal polybasic region. It has been postulated that these two regulatory sequences may function together, enabling Rac1 to participate in nuclear signaling pathways that ultimately target it for degradation. We have previously shown that the NLS activity of Rac1 and the Rac1b splice variant is...
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