Article
AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts.
The Journal of clinical investigation - 1 Oct 2007
Zhang Jing, Park Serk In, Artime Marlene C, Summy Justin M, Shah Ami N, Bomser Joshua A, Dorfleutner Andrea, Flynn Daniel C, Gallick Gary E
Abstract excerpt
The actin filament-associated protein AFAP-110 is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP-110 regulates actin cytoskeleton integrity but also functions as an adaptor protein that affects crosstalk between Src and PKC. Here we investigated the roles of AFAP-110 in the tumorigenic process of prostate carcinoma. Using immunohistochemistry of human tissue...
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