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Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole

1 Oct 2007

Abstract excerpt

OBJECTIVE: The aim of the study was to identify changes in tumour expression profiling associated with short-term therapy of breast cancer patients with letrozole. EXPERIMENTAL DESIGN: Microarray analysis was performed on RNA extracted from paired tumour core biopsies taken before and after 14 days of treatment with letrozole (2.5 mg/daily) in 58 patients. Changes in expression profile were identified by three...

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PMID: 17885619
DOI: 10.1097/fpc.0b013e32820b853a

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