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Article

c-Cbl is not required for ERK1/2-dependent degradation of BimEL.

Cellular signalling - 1 Dec 2007

Wiggins Ceri M, Band Hamid, Cook Simon J

Abstract excerpt

Bim(EL) the most abundant Bim splice variant, is subject to ERK1/2-catalysed phosphorylation, which targets it for ubiquitination and proteasome-dependent destruction. In contrast, inactivation of ERK1/2, following withdrawal of survival factors, promotes stabilization of Bim(EL). It has been proposed that the RING finger protein Cbl binds to Bim(EL) and serves as its E3 ubiquitin ligase. However, this is...

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Identifiers

PMID: 17884340
DOI: 10.1016/j.cellsig.2007.08.008
PMCID: PMC2707770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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