Article
Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Jan 2008
Domschke Katharina, Hohoff Christa, Mortensen Lena S, Roehrs Tilmann, Deckert Jürgen, Arolt Volker, Baune Bernhard T
Abstract excerpt
The monoamine oxidase A (MAO-A) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of Major Depression. In the present study, 340 patients with a Major Depressive Episode (f=194, m=146; DSM-IV) of Caucasian descent were genotyped for the functional MAO-A VNTR. The clinical response to antidepressive pharmacological treatment was assessed by weekly intra-individual...
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