Article
Vitamin D receptor haplotypes protect against development of colorectal cancer.
European journal of clinical pharmacology - 1 Nov 2007
Flügge Jana, Krusekopf Solveigh, Goldammer Mark, Osswald Elena, Terhalle Werner, Malzahn Uwe, Roots Ivar
Abstract excerpt
OBJECTIVE: We investigated the association of vitamin D receptor polymorphisms and colorectal cancer incidence in a Caucasian population. METHODS: Frequencies of the vitamin D receptor gene polymorphisms 23005G>A (CDX-2), 27823C>T (FokI), 60890G>A (BsmI), 61050G>A (Tru9I), 61888G>T (ApaI), and 61968T>C (TaqI) were determined in a series of 256 colorectal cancer patients and 256 patients without malignant disease...
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