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Article

Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence.

Biological psychiatry - 15 Jan 2008

Kakko Johan, von Wachenfeldt Joachim, Svanborg Kerstin Dybrandt, Lidström Jessica, Barr Christina S, Heilig Markus

Abstract excerpt

BACKGROUND: Heroin dependence is associated with a hyperactive hypothalamic-pituitary-adrenal (HPA) axis, proposed as a biological correlate of craving. Maintenance treatment with methadone normalizes HPA axis activity. Here, we examined HPA axis activity under maintenance treatment with the increasingly utilized partial opiate agonist buprenorphine. METHODS: Responses to a metyrapone challenge were compared in...

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Source

Identifiers

PMID: 17850768
DOI: 10.1016/j.biopsych.2007.05.001

Genes

OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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