Diet and the evolution of human amylase gene copy number variation.

doi:10.1038/ng2123

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Article

Diet and the evolution of human amylase gene copy number variation.

Nature genetics - 1 Oct 2007

Perry George H, Dominy Nathaniel J, Claw Katrina G, Lee Arthur S, Fiegler Heike, Redon Richard, Werner John, Villanea Fernando A, Mountain Joanna L, Misra Rajeev, Carter Nigel P, Lee Charles, Stone Anne C

Abstract excerpt

Starch consumption is a prominent characteristic of agricultural societies and hunter-gatherers in arid environments. In contrast, rainforest and circum-arctic hunter-gatherers and some pastoralists consume much less starch. This behavioral variation raises the possibility that different selective pressures have acted on amylase, the enzyme responsible for starch hydrolysis. We found that copy number of the...

Topics

Animals
Diet
Evolution, Molecular
Gene Dosage
Genetic Variation
Humans
Starch
alpha-Amylases

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Identifiers

PMID: 17828263
DOI: 10.1038/ng2123
PMCID: PMC2377015

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