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Article

Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2007

Holt Ian, Mittal Saloni, Furling Denis, Butler-Browne Gillian S, Brook J David, Morris Glenn E

Abstract excerpt

Nuclear speckles are storage sites for small nuclear RNPs (snRNPs) and other splicing factors. Current ideas about the role of speckles suggest that some pre-mRNAs are processed at the speckle periphery before being exported as mRNA. In myotonic dystrophy type 1 (DM1), the export of mutant DMPK mRNA is prevented by the presence of expanded CUG repeats that accumulate in nuclear foci. We now show that these foci...

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Source

Identifiers

PMID: 17825047
DOI: 10.1111/j.1365-2443.2007.01112.x

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles.PMID 17825047Read ↗

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