Article
Distinct single nucleotide polymorphism pattern at the FUT2 promoter among human populations.
Annals of hematology - 1 Jan 2008
Soejima Mikiko, Koda Yoshiro
Abstract excerpt
Many single nucleotide polymorphisms (SNPs) have been identified in the coding region of the FUT2 locus, which encodes secretor type alpha(1,2)fucosyltransferase. In this study, we analyzed the sequence variations in the proximal promoter region of FUT2 in several human populations. In African populations, we found two SNPs with intermediate frequency that affected the promoter activity in vitro with a cell...
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