Article
Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population.
Acta diabetologica - 1 Mar 2008
Badii Ramin, Bener Abdulbari, Zirie Mahmoud, Al-Rikabi Ammar, Simsek Mehmet, Al-Hamaq Abdulla O A A, Ghoussaini Maya, Froguel Philippe, Wareham Nick J
Abstract excerpt
Peroxisome proliferators-activated receptor gamma (PPAR gamma) is a nuclear hormone receptor that serves as a master regulator for adipocytes-specific genes contributing to adipocytes differentiation, insulin sensitivity and lipid metabolism. The substitution of proline to alanine at codon 12 of the PPAR gamma 2 gene (Pro12Ala polymorphism) is most widely studied, and the associations with diabetes, obesity, and...
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