Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone Morphogenetic Protein Signaling Suppresses Tumorigenesis at Gastric Epithelial Transition Zones in Mice

1 Sept 2007

Abstract excerpt

Bone morphogenetic protein (BMP) signaling is known to suppress oncogenesis in the small and large intestine of mice and humans. We examined the role of Bmpr1a signaling in the stomach. On conditional inactivation of Bmpr1a, mice developed neoplastic lesions specifically in the squamocolumnar and gastrointestinal transition zones. We hypothesized that the regulation of epithelial cell fate may be less well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to TGF-β signaling in diseases
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17804727
DOI: 10.1158/0008-5472.can-06-4659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone Morphogenetic Protein Signaling Suppresses Tumorigenesis at Gastric Epithelial Transition Zones in MicePMID 17804727Read ↗

Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein SignalingSemantic proximity Read ↗

BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal TractSemantic proximity Read ↗

Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in miceSemantic proximity Read ↗

GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche via stromal remodellingSemantic proximity Read ↗

Bmp signaling is required for intestinal growth and morphogenesisSemantic proximity Read ↗

Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formationSemantic proximity Read ↗

The critical role of BMP signaling in gastric epithelial cell differentiation revealed by organoidsSemantic proximity Read ↗

BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell statesSemantic proximity Read ↗

De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse IntestineSemantic proximity Read ↗

Wnt signaling and gastrointestinal tumorigenesis in mouse models.Semantic proximity Read ↗

Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.Semantic proximity Read ↗

Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.