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Article

Bmp signaling is required for intestinal growth and morphogenesis

14 Mar 2006

Abstract excerpt

Intestinal growth, morphogenesis, differentiation, and homeostasis are regulated by reciprocal interactions between the epithelium and the underlying mesenchymal stroma. The identification of BMPR1A mutations in patients with Juvenile Polyposis implicates Bmp signaling as an important mediator of these interactions. To test this hypothesis, we inhibited Bmp signaling in the mouse proximal intestine by transgenic...

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PMID: 16538672
DOI: 10.1002/dvdy.20741

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