Article
Dedicated epithelial recipient cells determine pigmentation patterns.
Cell - 7 Sept 2007
Weiner Lorin, Han Rong, Scicchitano Bianca M, Li Jian, Hasegawa Kiyotaka, Grossi Maddalena, Lee David, Brissette Janice L
Abstract excerpt
Mammals generate external coloration via dedicated pigment-producing cells but arrange pigment into patterns through mechanisms largely unknown. Here, using mice as models, we show that patterns ultimately emanate from dedicated pigment-receiving cells. These pigment recipients are epithelial cells that recruit melanocytes to their position in the skin and induce the transfer of melanin. We identify Foxn1 (a...
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