Article
The evolution of genome compression and genomic novelty in RNA viruses.
Genome research - 1 Oct 2007
Belshaw Robert, Pybus Oliver G, Rambaut Andrew
Abstract excerpt
The genomes of RNA viruses are characterized by their extremely small size and extremely high mutation rates (typically 10 kb and 10(-4)/base/replication cycle, respectively), traits that are thought to be causally linked. One aspect of their small size is the genome compression caused by the use of overlapping genes (where some nucleotides code for two genes). Using a comparative analysis of all known RNA viral...
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