Article
Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia.
Brain pathology (Zurich, Switzerland) - 1 Oct 2007
Derfuss Tobias, Segerer Stephan, Herberger Simone, Sinicina Inga, Hüfner Katharina, Ebelt Kathleen, Knaus Hans-Gunther, Steiner Israel, Meinl Edgar, Dornmair Klaus, Arbusow Viktor, Strupp Michael, Brandt Thomas, Theil Diethilde
Abstract excerpt
The latent persistence of herpes simplex virus type 1 (HSV-1) in human trigeminal ganglia (TG) is accompanied by a chronic CD8 T-cell infiltrate. The focus of the current work was to look for HSV-1 transcription activity as a potential trigger of the immune response and to characterize the immune cell infiltrates by this feature. We combined in situ hybridization, laser cutting microscopy, and single cell RT-PCR...
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