Article
Influence of peroxisome proliferator-activated receptor (PPAR)gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese.
Digestive diseases and sciences - 1 Mar 2008
Tahara Tomomitsu, Arisawa Tomiyasu, Shibata Tomoyuki, Nakamura Masakatsu, Wang Fangyu, Maruyama Naoko, Kamiya Yoshio, Nakamura Masahiko, Fujita Hiroshi, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Hirata Ichiro, Nakano Hiroshi
Abstract excerpt
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) has been shown to inhibit the proliferation of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. We investigated the influence of PPARgamma gene Plo12Ala polymorphism on the risk of gastric cancer and on the severity of Helicobacter...
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