Article
HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome.
Arthritis and rheumatism - 1 Sept 2007
Vaglio Augusto, Martorana Davide, Maggiore Umberto, Grasselli Chiara, Zanetti Adele, Pesci Alberto, Garini Giovanni, Manganelli Paolo, Bottero Paolo, Tumiati Bruno, Sinico Renato A, Savi Mario, Buzio Carlo, Neri Tauro M
Abstract excerpt
OBJECTIVE: To explore the association between HLA alleles and Churg-Strauss syndrome (CSS), and to investigate the potential influence of HLA alleles on the clinical spectrum of the disease. METHODS: Low-resolution genotyping of HLA-A, HLA-B, and HLA-DR loci and genotyping of TNFA -238A/G and TNFA -308A/G single-nucleotide polymorphisms were performed in 48 consecutive CSS patients and 350 healthy controls....
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