Article
Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2007
Dumont Julie, Zureik Mahmoud, Bauters Christophe, Grupposo Marie-Catherine, Cottel Dominique, Montaye Michèle, Hamon Martial, Ducimetière Pierre, Amouyel Philippe, Brousseau Thierry
Abstract excerpt
OBJECTIVE: Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Therefore, we sought for association between OAZ1 gene polymorphisms and various outcomes involving VSMC proliferation....
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