Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in p53 mutant human colon cancer.

Journal of experimental & clinical cancer research : CR - 1 Jun 2007

Tanaka K, Inoue Y, Hiro J, Yoshiyama S, Toiyama Y, Eguchi T, Miki C, Kusunoki M

Abstract excerpt

IFL [irinotecan (CPT-11), 5-fluorouracil (5-FU), and folinic acid] is one of the treatments for metastatic colorectal cancer. We evaluated cytotoxic effects of a sequentially administered a combination of 5-FU with CPT-11 in human p53 mutant colon cancer. Sequential combination of 5-FU and CPT-11 in human colon cancer SW480 cells using a WST-8 colorimetric assay was studied. Cytotoxicity and cell cycle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Camptothecin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Drug Administration Schedule

Share to Fluorouracil

Share to Irinotecan

Share to Leucovorin

Share to Up-Regulation

Source

Identifiers

PMID: 17725105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in p53 mutant human colon cancer.PMID 17725105Read ↗

Schedule-dependent cytotoxicity of SN-38 in p53 wild-type and mutant colon adenocarcinoma cell lines.Semantic proximity Read ↗

Sequence-dependent growth inhibition and DNA damage formation by the irinotecan–5-fluorouracil combination in human colon carcinoma cell linesSemantic proximity Read ↗

In-vitro schedule-dependent interaction between oxaliplatin and 5-fluorouracil in human gastric cancer cell linesSemantic proximity Read ↗

The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.Semantic proximity Read ↗

5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteinsSemantic proximity Read ↗

Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line.Semantic proximity Read ↗

Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.Semantic proximity Read ↗

p53 dependence and apoptosis in response to FP treatment with p53-transfected colon cancer cell lines by use of thin layer collagen gel.Semantic proximity Read ↗

Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).Semantic proximity Read ↗

Efficient induction of apoptosis by ONYX-015 adenovirus in human colon cancer cell lines regardless of p53 status.Semantic proximity Read ↗

Dependence of chemotherapy response on p53 mutation status in a panel of human cancer lines maintained in nude mice.Semantic proximity Read ↗

Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell lineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.