Article
Dependence of chemotherapy response on p53 mutation status in a panel of human cancer lines maintained in nude mice.
Cancer science - 1 Jun 2004
Koike Masako, Fujita Fumiko, Komori Kinuyo, Katoh Fumitaka, Sugimoto Takuji, Sakamoto Yasuo, Matsuda Masato, Fujita Masahide
Abstract excerpt
In contrast to findings in vitro, the clinical response to anticancer chemotherapy is not simply associated with the p53 mutation status. To analyze the relationship between the actual response of solid tumors with p53 mutation and other biological characteristics, we used a human cancer-nude mouse panel of 21 lines derived from stomach, colorectal, breast, lung, and liver cancers for experimental chemotherapy....
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