Article
Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine.
Antimicrobial agents and chemotherapy - 1 Nov 2007
Ntemgwa Michel, Wainberg Mark A, Oliveira Maureen, Moisi Daniela, Lalonde Richard, Micheli Valeria, Brenner Bluma G
Abstract excerpt
Mutations in the RNase H domain of human immunodeficiency virus type 1 RT have been reported to cause resistance to zidovudine (ZDV) in vitro. However, very limited data on the in vivo relevance of these mutations in patients exist to date. This study was designed to determine the relationship between mutations in the RNase H domain and viral susceptibility to nucleoside analogues. Viruses harboring complex...
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