Article
Metabolic network analysis of Pseudomonas aeruginosa during chronic cystic fibrosis lung infection.
Journal of bacteriology - 1 Oct 2010
Oberhardt Matthew A, Goldberg Joanna B, Hogardt Michael, Papin Jason A
Abstract excerpt
System-level modeling is beginning to be used to decipher high throughput data in the context of disease. In this study, we present an integration of expression microarray data with a genome-scale metabolic reconstruction of Pseudomonas aeruginosa in the context of a chronic cystic fibrosis (CF) lung infection. A genome-scale reconstruction of P. aeruginosa metabolism was tailored to represent the metabolic...
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