Article
Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene.
Genomics - 1 Oct 2007
King Kathy, Bagnall Richard, Fisher Sheila A, Sheikh Faisal, Cuthbert Andrew, Tan Sipin, Mundy Nicholas I, Rosenstiel Philip, Schreiber Stefan, Mathew Christopher G, Roberts Roland G
Abstract excerpt
Mutations in the NOD2 (CARD15) gene predispose to Crohn's disease (CD), a human chronic inflammatory bowel disorder, and can cause Blau syndrome. During an investigation of an apparent correlation between a frameshifting mutation in the canonical first exon of NOD2 of marmoset and tamarin species and their susceptibility to chronic colitis, we found that, contrary to previous reports, the basal levels of NOD2...
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