Analysis of the In Vitro Transcriptional Response of Human Pharyngeal Epithelial Cells to AdherentStreptococcus pneumoniae: Evidence for a Distinct Response to Encapsulated Strains

Abstract excerpt

Infection of the human host by Streptococcus pneumoniae begins with colonization of the nasopharynx, which is mediated by the adherence of bacteria to the respiratory epithelium. Several studies have indicated an important role for the pneumococcal capsule in this process. Here, we used microarrays to characterize the in vitro transcriptional response of human pharyngeal epithelial Detroit 562 cells to the...

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