Article
Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic children.
International archives of allergy and immunology - 1 Jan 2008
Szczepankiewicz Aleksandra, Breborowicz Anna, Skibińska Maria, Wiłkość Monika, Tomaszewska Marta, Hauser Joanna
Abstract excerpt
BACKGROUND: FYN is nonreceptor tyrosine kinase that represents the earliest detectable signaling response after antigen-activated inflammatory cells. Studies in animal models of allergic asthma have shown that inhibitors of tyrosine kinases exert an anti-inflammatory effect. In the FYN gene, several polymorphisms have been described. There have, however, been no studies analyzing the impact of FYN gene...
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