Article
Optical and biochemical dissection of connexin and disease-linked connexin mutants in 3D organotypic epidermis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Langlois Stéphanie, Churko Jared M, Laird Dale W
Abstract excerpt
The epidermis is a complex tissue composed principally of differentiated keratinocytes that form a keratinized stratified squamous epithelium. The gap junction proteins, connexins (Cx), are differentially expressed throughout the stratified layers of the epidermis and their exquisite regulation appears to govern the delicate balance between cell proliferation and differentiation in normal skin homeostasis and in...
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