Article
Heterogeneity of PLAG1 gene rearrangements in pleomorphic adenoma.
Cancer genetics and cytogenetics - 1 Aug 2007
Kandasamy Jothy, Smith Arabella, Diaz Sara, Rose Barbara, O'Brien Christopher
Abstract excerpt
Pleomorphic adenoma (PA), a benign mixed salivary gland tumor, has been associated with abnormal karyotypes in up to 70% of cases, with nonrandom involvement of 8q12, the locus of the pleomorphic adenoma (PLAG1) gene. In this study, cytogenetics and fluorescence in situ hybridization (FISH) were used to investigate PLAG1 involvement in PA from seven patients. There were two males and five females ranging in age...
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