Article
Leveraging information across HLA alleles/supertypes improves epitope prediction.
Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2000
Heckerman David, Kadie Carl, Listgarten Jennifer
Abstract excerpt
We present a model for predicting HLA class I restricted CTL epitopes. In contrast to almost all other work in this area, we train a single model on epitopes from all HLA alleles and supertypes, yet retain the ability to make epitope predictions for specific HLA alleles. We are therefore able to leverage data across all HLA alleles and/or their supertypes, automatically learning what information should be shared...
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