Article
EGFR exon 20 insertion mutation in Japanese lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2007
Sasaki Hidefumi, Endo Katsuhiko, Takada Minoru, Kawahara Masaaki, Kitahara Naoto, Tanaka Hisaichi, Okumura Meinoshin, Matsumura Akihide, Iuchi Keiji, Kawaguchi Tomoya, Kawano Osamu, Yukiue Haruhiro, Yokoyama Tomoki, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
Mutations of the epidermal growth factor receptor (EGFR) gene have been reported in non-small cell lung cancer (NSCLC), especially in female, never smoker patients with adenocarcinoma. Some common somatic mutations in EGFR, including deletion mutations in exon 19 and leucine to arginine substitution at amino acid position 858 (L858R) in exon 21, have been examined for their ability to predict sensitivity to...
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