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Article

Clinicopathological characteristics of 11 NSCLC patients with EGFR-exon 20 mutations.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2012

Lund-Iversen Marius, Kleinberg Lilach, Fjellbirkeland Lars, Helland Åslaug, Brustugun Odd Terje

Abstract excerpt

INTRODUCTION: The characteristics of different types of epidermal growth factor receptor (EGFR) gene mutations in non-small-cell lung cancer (NSCLC) are not extensively studied. The distribution of EGFR mutations is known, with the most frequent in exon 19 (deletions) or exon 21 (point mutations). Aberrations in exon 18 or 20 are infrequently found. Point mutations in exon 20 confer resistance against tyrosine...

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Identifiers

PMID: 22895145
DOI: 10.1097/JTO.0b013e3182614a9d

Genes

EGFR

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