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Article

Contribution of A1 subunit residue Q316 in thrombin-activated factor VIII to A2 subunit dissociation.

Biochemistry - 28 Aug 2007

Parker Ernest T, Lollar Pete

Abstract excerpt

Blood coagulation factor VIII (fVIII) is activated by thrombin to form an A1/A2/A3-C1-C2 heterotrimer, which functions as a cofactor for factor IXa during intrinsic pathway factor X activation. Human thrombin-activated fVIII (fVIIIa) decays rapidly because of first-order dissociation of the A2 subunit, which may function to regulate the coagulation mechanism. The three fVIII A domains each consist of two...

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Identifiers

PMID: 17676877
DOI: 10.1021/bi700941w
PMCID: PMC2525606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Contribution of A1 subunit residue Q316 in thrombin-activated factor VIII to A2 subunit dissociation.PMID 17676877Read ↗

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