Article
TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder.
Pathology - 1 Aug 2007
Saetta Angelica A, Korkolopoulou Penelope, Karlou Maria, Levidou Georgia, Goudopoulou Athina, Thymara Irene, Stamatelli Angeliki, Tzivras Michalis, Michalopoulos Nikolaos V, Thomas-Tsagli Euphemia, Patsouris Efstratios
Abstract excerpt
AIM: The aim of this study was to determine the potential synchronous contribution of alterations in TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes to the development and clinical outcome of bladder cancer, in relation to p53 mutations, microsatellite status and hMLH1/hMSH2 expression. METHODS: Molecular biology techniques as well as immunohistochemistry were applied in 69 samples from patients with...
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