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Article

Voriconazole and fluconazole increase the exposure to oral diazepam.

European journal of clinical pharmacology - 1 Oct 2007

Saari Teijo I, Laine Kari, Bertilsson Leif, Neuvonen Pertti J, Olkkola Klaus T

Abstract excerpt

OBJECTIVE: We assessed the effect of voriconazole and fluconazole on the pharmacokinetics and pharmacodynamics of diazepam. METHODS: Twelve healthy volunteers took 5 mg of oral diazepam in a randomised order on three study sessions: without pretreatment, after oral voriconazole 400 mg twice daily on the first day and 200 mg twice daily on the second day, or after oral fluconazole 400 mg on the first day and 200...

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Source

Identifiers

PMID: 17676319
DOI: 10.1007/s00228-007-0350-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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