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Article

Beyond toothpicks: new methods for isolating mutant bacteria.

Nature reviews. Microbiology - 1 Sept 2007

Link A James, Jeong Ki Jun, Georgiou George

Abstract excerpt

Over the past 50 years genetic analysis in microbiology has relied predominantly on selections and plate assays using chromogenic enzyme substrates - for example, X-gal assays for the detection of beta-galactosidase activity. Recent advances in fluorescent assays and high throughput screening technologies have paved the way for the rapid isolation of mutants that confer complex phenotypes and for the quantitative...

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PMID: 17676054
DOI: 10.1038/nrmicro1715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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